6-(substituted)methylenepenicillanic and 6-(substituted)hydroxym

Details 6-(substituted)methylenepenicillanic and 6-(substituted)hydroxym 6-(substituted)methylenepenicillanic and 6-(substituted)hydroxym

1989-01-13

1991-05-14

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Plural fermentates of different origin

540310, 514192, 514195, C07D49900, A61K 31425

Patent

active

050154737

ABSTRACT:
Beta-lactamase inhibiting compounds of the formula ##STR1## or a pharmaceutically acceptable acid addition or carboxylate salt thereof; where n is zero, 1 or 2; X.sub.3 is H or Br, R.sup.1 is H, the residue of certain carboxy-protecting groups or the residue of an ester group readily hydrolyzable in vivo; one of R.sup.12 and R.sup.13 is H and the other is vinyl, certain aryl, alkylthio, alkylsulfonyl or certain heterocyclyl, aminomethyl, thiocarboxyamido or amidino groups; one of R.sup.2 and R.sup.3 is H and the other is as disclosed for the other of R.sup.12 and R.sup.13, or is Cl or CH.sub.2 OH, and R.sup.18 is H or certain acyl groups; intermediates useful in their production, methods for their preparation and use, and pharmaceutical compositions containing them.

REFERENCES:
patent: 4143046 (1979-03-01), Sheehan et al.
patent: 4287181 (1981-09-01), Kellogg
patent: 4419284 (1983-12-01), Crawford
patent: 4485110 (1984-11-01), Osborne
patent: 4512999 (1987-04-01), Adam-Molina

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