6-(Substituted-hydroxymethylene penams)

Details 6-(Substituted-hydroxymethylene penams) 6-(Substituted-hydroxymethylene penams)

1978-06-02

1981-06-09

Rizzo, Nicholas S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424270, 544 21, C07D27760

Patent

active

042724392

ABSTRACT:
.beta.-Lactams having a substituted hydroxymethylene group at the position .alpha. to the lactam carbonyl group are prepared by reaction of an .alpha.-halo-.beta.-lactam with zinc or zinc amalgam in an anhydrous aprotic medium to produce an intermediate which in situ reacts with an appropriate aldehyde or ketone.
Also described are noval penicillins and cephalosporins having useful antibacterial activity.

REFERENCES:
patent: 3936446 (1976-02-01), Bentley et al.
patent: 3950352 (1976-04-01), Wolfe
patent: 4076826 (1977-02-01), Christensen et al.
patent: 4078068 (1978-03-01), Christensen et al.
patent: 4123539 (1978-10-01), Dininno
patent: 4172837 (1979-10-01), Dininno
Dininno et al., Jour. Org. Chem., 42, 2960-2965 (1977).

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