6-substituted furo-(3,4-c)-pyridine derivatives and anti-depress

Details 6-substituted furo-(3,4-c)-pyridine derivatives and anti-depress 6-substituted furo-(3,4-c)-pyridine derivatives and anti-depress

1985-01-23

1986-04-08

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546116, A61K 3144, C07D491048

Patent

active

045813620

ABSTRACT:
This invention relates to new 1,3-dihydro-6-(1-hydroxy-2-dimethylaminomethyl-allyl)-7-hydroxy-furo-(3,4- c)-pyridine derivatives of the general formula: ##STR1## wherein, each of A.sub.1 and A.sub.2 independently, represents various substituents, to a process for the preparation of these compounds comprising reacting a 6-formyl-7-benzyloxy-furo-(3,4-c)-pyridine derivative of the general formula II ##STR2## with 1-dimethylaminomethyl-vinylmagnesium bromide at the boil, in a non polar solvent and hydrolyzing the 7-benzyloxy group and to a therapeutic composition of matter, comprising as an essential ingredient therein, at least one of these compounds. The compounds according to the invention are of interest for their therapeutic activity, principally as anti-depressive agents.

REFERENCES:
patent: 4383998 (1983-05-01), Esanu
Robert Morrison and Robert Boyd, "Organic Chemistry", 2nd Ed., Allyn and Bacon, Inc., 1966 (Boston).

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