6-Substituted derivatives of clavulanic acid

Details 6-Substituted derivatives of clavulanic acid 6-Substituted derivatives of clavulanic acid

1982-04-20

1986-02-18

Berch, Mark L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

2602453, C07D44804, A61K 3142

Patent

active

045713928

ABSTRACT:
The present invention provides the compounds of the formula (II): ##STR1## and salts and esters thereof wherein R.sub.1 is a hydrogen atom or an alkyl group of 1-4 carbon atoms and R.sub.2 is a hydrogen atom or an alkyl group of 1-4 carbon atoms or is joined to R.sub.1 to form part of a 5-, 6- or 7 membered carbocyclic ring. These compounds are .beta.-lactamase inhibitors able to enhance the effectiveness of pencillins and cephalosporins. Their preparation and compositions containing them are described.

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