Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Cyclopentanohydrophenanthrene ring system doai
Patent
1986-07-07
1989-02-28
Schenkman, Leonard
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Cyclopentanohydrophenanthrene ring system doai
2603973, A61K 3156, C07J 100
Patent
active
048086169
ABSTRACT:
The invention relates to 6-alkylidenandrosta-1,4-diene-3,17-dione derivatives, having the following general formula ##STR1## wherein each of R and R.sub.2, independently, is hydrogen or C.sub.1 -C.sub.6 alkyl and R.sub.1 is hydrogen, halogen or C.sub.1 -C.sub.6 alkyl, which are useful in therapy, in particular in the treatment of hormone-dependent cancers.
REFERENCES:
patent: 2744120 (1956-05-01), Fried et al.
patent: 3112305 (1963-11-01), Kirk et al.
patent: 4235893 (1980-11-01), Brodie et al.
patent: 4322349 (1982-03-01), Annen et al.
patent: 4512986 (1985-04-01), Reel et al.
patent: 4591585 (1986-05-01), Kerb et al.
Petrow, et al "Prostatic Cancer-II, . . . " Chemical Abstracts vol. 100, 1984, p. 84.
Derwent Abstract of Belgian patent No. 816,364.
Derwent Abstract of German patent No. 3422-187-A.
"Aromatase Inhibitors, Synthesis and Biological Activity of Andostenedione Derivatives", David A. Marsh et al, J. Med. Chem, 185, pp. 788-795.
Schering AG, "New 1-alky-androsta-1,4-diene-3,17-dione . . . " Pharmaceuticals, p. 9, 1984.
Brodie, A. "Overview of Recent Developments of Aromatase Inhibitors", Cancer Research (Suppl.) 42, 3312s-3314 Aug. 1982).
Covey, et al "A New Hypothesis Based on Suicide Substrate . . . " Cancer Research (Suppl) 42, 3327s-3333s Aug. 1982.
Farmdoc Abstract U.S. 4289-762 Rich 27 06 80.
Farmdoc Abstract U.S. Pat. No. 4322-416.
Metcalf et al "Substrate-Induced Inactivation of Aromatase . . . " J. Am. Chem. Soc. 1981 103, 3221-3222.
Derwent Publications Ltd. EP 100 566A.
Farmdoc Abstracts GB No. 2100-601.
Chemical Abstracts U.S. No. 3,117,966 (Petrow) vol. 60 9336.
Chemical Abstracts U.S. Pat. No. 3,112,305. vol. 60, 9337.
Farmdoc Abstract, SA 65/4327.
Farmdoc Abstract, U.S. No. 3,356,694.
Korp et al, "Efficient Synthesis and Mechanisms of Formation . . . " J.C.S. Chem. Comm. 1973, pp. 72-73.
Barbugian Natale
Buzzetti Franco
Di Salle Enrico
Lombardi Paolo
Farmitalia Carlo Erba S.r.l.
Lipovsky Joseph A.
Schenkman Leonard
LandOfFree
6-substituted androsta-1,4-diene-3,17-diones does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with 6-substituted androsta-1,4-diene-3,17-diones, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 6-substituted androsta-1,4-diene-3,17-diones will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1367512