6 Substituted amino-2-substituted-pen-2-em-3-carboxylic acid

Details 6 Substituted amino-2-substituted-pen-2-em-3-carboxylic acid 6 Substituted amino-2-substituted-pen-2-em-3-carboxylic acid

1978-10-10

1980-07-29

Morgenstern, Norman

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

2602391, 2602452R, 424244, 424246, 4242484, 42424851, 424249, 424250, 424256, 424270, 424269, 424271, A61K 3143, C07D27702, C07D49944

Patent

active

042151244

ABSTRACT:
Disclosed are 6-substituted amino-2-substituted-pen-2-em-3-carboxylic acids of the following structure: ##STR1## wherein R.sup.1 is hydrogen or acyl, R.sup.2 is hydrogen or methoxyl, and R.sup.3 is inter alia, hydrogen, --R, --OR, --SR, --NR.sub.2, R is alkyl, aryl, aralkyl, heterocyclyl or heterocyclylalkyl; n is 0 or 1; when n=1, R.sup.3 is not --SR.
Such compounds and their pharmaceutically acceptable salt, and ester derivatives are useful as antibiotics. Also disclosed are processes for the preparation of such compounds, pharmaceutical compositions comprising such compounds and methods of treatment comprising administering such compounds and compositions when an antibiotic effect is indicated.

REFERENCES:
patent: 4070477 (1978-01-01), Ernest et al.

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