6-substituted alkoxy-2-oxo-1,2-dihydroquinoxaline derivatives

Details 6-substituted alkoxy-2-oxo-1,2-dihydroquinoxaline derivatives 6-substituted alkoxy-2-oxo-1,2-dihydroquinoxaline derivatives

1988-10-05

1989-09-26

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

548253, 560 22, 544391, 546226, C07D24144, C07D40112, C07D40312, A61K 31495

Patent

active

048701750

ABSTRACT:
A compound of the formula ##STR1## wherein Z is N or NH, is a single or double bond, R.sub.1 is hydrogen, C.sub.1-20 alkyl or optionally substituted phenyl, A is lower alkylene, R is carboxyl, lower alkoxycarbonyl, ##STR2## or 1-cycloalkyl-tetrazole-5-yl, R.sub.2 is lower alkyl, hydroxy-lower alkyl or optionally substituted phenyl-lower alkyl, R.sub.3 is lower alkyl or cycloalkyl, or R.sub.2 and R.sub.3 together constitute ##STR3## and R.sub.5 and R.sub.6 are hydrogen or optionally substituted phenyl, or a pharmacologically acceptable salt thereof, has platelet aggregation inhibitory activity and/or cyclic AMP/phosphodiesterase inhibitory activity.

REFERENCES:
patent: 4167512 (1979-09-01), Lai
patent: 4296114 (1981-10-01), Appleton et al.
patent: 4466916 (1984-08-01), Lai et al.
patent: 4636246 (1987-01-01), Plath et al.

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