6-substituted-1,2,3,4-tetrahydroisoquinolines

Details 6-substituted-1,2,3,4-tetrahydroisoquinolines 6-substituted-1,2,3,4-tetrahydroisoquinolines

1989-10-13

1990-10-16

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514310, 546143, 546146, 546147, 546148, 546149, A61K 3147, C07D40906

Patent

active

049635638

ABSTRACT:
Compounds of the formula: ##STR1## wherein n=1 or 2; R.sub.1 is lower alkoxy, lower alkyl, halo, ester, carbamate, or substituted amino; and R.sub.2 is thienyl or furyl; or R.sub.2 is ##STR2## wherein R.sub.3 and R.sub.4 are independently selected from hydrogen, halo, hydroxy, methoxy, thioalkoxy, substituted amino and lower alkyl; and pharmaceutically acceptable salts thereof.
These compounds are useful as inhibitors of alpha-2-adrenergic receptors and for the treatment of glaucoma and/or controlling intraocular pressure.

REFERENCES:
patent: 4261998 (1981-04-01), Najer
patent: 4766131 (1988-08-01), Davidson et al.
patent: 4885302 (1989-12-01), George et al.

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