Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1992-05-13
1994-01-11
Tsang, Cecilia
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514270, 544300, 544310, 544360, 544363, 544364, A61K 31505, C07D40112
Patent
active
052781674
ABSTRACT:
Novel 6-pyridyl substituted pyrimidine derivatives are disclosed for use as antiviral agents, particularly for the treatment of retroviral infections such as HIV infections and related disorders, as well as for use in anti-cancer therapies to improve the efficacy of anti-cancer therapeutics. These compounds and their pharmacologically acceptable salts operate to disrupt viral replication an exhibit lower cell toxicity, thereby providing more efficient agents for use alone or in conjunction with other chemical or biological agents to provide prolonged antiviral therapy. In addition, the compounds can be used to increase the efficacy of anti-cancer therapeutics including 5-fluropyrimidines such as 5-fluorouracil, thereby reducing the dosage requirement of the therapeutic in anti-cancer therapies so as to decrease toxic effects to the host.
REFERENCES:
patent: 3282921 (1966-11-01), Verheyden et al.
patent: 3755295 (1973-08-01), Verheyden et al.
patent: 3775397 (1973-11-01), Etzold et al.
patent: 3817982 (1974-07-01), Verheyden et al.
patent: 4071680 (1978-01-01), Cook
patent: 4093715 (1978-06-01), Liu et al.
patent: 4128639 (1978-12-01), Liu et al.
patent: 4210638 (1980-07-01), Greer
patent: 4230698 (1980-10-01), Bobek et al.
patent: 4331662 (1982-05-01), Eckstein et al.
patent: 4604382 (1986-08-01), Liu et al.
patent: 4681933 (1987-07-01), Chu et al.
Horwitz, J. Org. Chem. vol. 29, pp. 2076-2078 (1964).
Liu et al, J. Med. Chem. pp. 109-112 (1978).
Liu et al, Biochem. Pharmacol. vol. 36, pp. 311-316 (1987).
Cheng Yung C.
Chu Shih H.
Pan Bai C.
Brown University Research Foundation
Engellenner Thomas J.
Tsang Cecilia
Vincent Matthew P.
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