Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1985-12-23
1988-01-19
Rizzo, Nicholas S.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
544276, 544265, C07D47330, A61K 3152
Patent
active
047204974
ABSTRACT:
6-purinyl N-(2-chloroethyl) carbamate and thiocarbamate are disclosed of the general formula I, ##STR1## in which X stands for an oxygen or sulfur atom, and also a process for their preparation by reacting a purine derivative of the general formula II (hypoxanthine or 6-mercaptopurine, respectively) with 2-chloroethylisocyanate. The subject compounds of formula I show a remarkable antineoplastic effect in vitro and in vivo, and consequently have great potential for the treatment of malignant neoplastic diseases in mammals.
REFERENCES:
patent: 4443435 (1984-04-01), Bodor et al.
Beitova Marta
Cerny Antonin
Grimova Jaroslava
Kejhova Irena
Krepelka Jiri
Rizzo Nicholas S.
SPOFA, spojene podniky pro zdravotnickou vyrobu
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