6-position cyclosporin a analogs as modifiers of cytotoxic drug

Details 6-position cyclosporin a analogs as modifiers of cytotoxic drug 6-position cyclosporin a analogs as modifiers of cytotoxic drug

1991-08-23

1993-08-17

Chan, Y. Christina

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514885, 514908, 514922, 514970, 530321, A61K 3702, C07K 764

Patent

active

052368998

ABSTRACT:
Cyclosporin analogs containing a MeAla or MeAbu residue at the 6-position of the cyclic undecapeptide have been discovered to sensitize multidrug resistant cells to certain chemotherapeutic agents. These cyclosporin analogs have also been shown to increase the sensitivity of cells already susceptible to the chemotherapeutic agents. In addition, these cyclosporin A analogs lack the nephrotoxic and immunosuppressive activity of cyclosporin A.

REFERENCES:
patent: 4108985 (1978-08-01), Ruegger et al.
patent: 4117118 (1978-09-01), Harri et al.
patent: 4210581 (1980-07-01), Ruegger et al.
patent: 4220641 (1980-09-01), Traber et al.
patent: 4288431 (1981-09-01), Traber et al.
patent: 4289851 (1981-09-01), Traber et al.
patent: 4384996 (1983-05-01), Bollinger et al.
patent: 4396542 (1983-08-01), Wenger
patent: 4639434 (1987-01-01), Wenger et al.
patent: 4681754 (1987-07-01), Sigel
patent: 4703033 (1987-10-01), Seebach
patent: 4914188 (1990-04-01), Dumont et al.
Suffness et al., J. Natural Products, vol. 45, pp. 1-14, (1982).
L. Slater, et al. Proc. Am. Assoc. Cancer Res. vol. 27 p. 392 (1986).
Wenger, R., Total Synthesis-Change in Molecular Structure-Biological Effect: Cyclosporin as Example, 1984/111 pp. 4-11.
Kobel and Traber, Directed Biosynthesis of Cyclosporins, 14 pp. 237-240 (1982).
Slater, et al., Cyclosporin A 27 p. 392 (1986).
Twentyman, et al., Cyclosporin A and its Analogues as Modifiers, 56 pp. 55-57 (1987).
Osieka, et al., Enhancement of Etoposide Induced Cytoxicity by Cyclosporin A, 18 pp. 198-202 (1986).
Nooter, et al. Effect of Cyclosporin A, 23 pp. 296-300 (1989).
Twentyman, Modification of Cytotoxic Drug Resistance, 57 pp. 254-258 (1988).
Twentyman, A Possible Role for Cyclosporins in Cancer Chemo. Anticancer Research, 8, pp. 985-994, (1988).

Affiliated with

Also associated with

Rating

6-position cyclosporin a analogs as modifiers of cytotoxic drug does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 6-position cyclosporin a analogs as modifiers of cytotoxic drug , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 6-position cyclosporin a analogs as modifiers of cytotoxic drug will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2243776