6-phosphogluconate dehydrogenase of Streptococcus pneumoniae

Details 6-phosphogluconate dehydrogenase of Streptococcus pneumoniae 6-phosphogluconate dehydrogenase of Streptococcus pneumoniae

1998-04-10

2000-12-19

Priebe, Scott D.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4353201, 435325, 4352523, 43525411, 536 231, 536 232, 536 237, C12N 1531, C12N 1552, C12N 1562, C12N 1563, C07H 2100

Patent

active

06162618&

ABSTRACT:
The invention provides 6-phosphogluconate dehydrogenase polypeptides and polynucleotides encoding 6-phosphogluconate dehydrogenase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing 6-phosphogluconate dehydrogenase polypeptides to screen for antibacterial compounds.

REFERENCES:
Tetaud, et al., "Lactococcus lactic 6-phosphogluconate dehydrogenase gene, complete cds, and potassium transporter homolog gene, partial cds.", GenBank Submission, Accession No. U74322, Apr. 7, 1998.
GenBank Submission, Accession No. U74322, Direct Submission, Apr. 7, 1998.
Marion N. Gilmour, et al., "Genetic Relationships Among the Oral Streptococci", Journal of Bacteriology, vol. 169, No. 11, pp. 5247-5257, Nov. 1987.
Hitomi Ohara, et al., "N A D--Specific 6-Phosphogluconate Dehydrogenase in Lactic Acid Bacteria", Biosci. Biotech. Biochem., vol. 60, No. 4, pp. 692-693, (1996).
S.L. Rowland, et al., "The Bacillus subtilus Cell-divison 135-137.degree. Region Contains an Essential orf with Significant Similarity to murB and a Dispensable sbp Gene", Gene, vol. 164, pp. 113-116, Elsevier Science B.V., Oct. 1995.
Ngo et al., "Computational complexity, protein structure prediction, and the Levinthal paradox", in The Protein Folding Problem and Tertiary Structure Prediction, Merz et al. (eds.), Birkhauser Boston: Boston, MA, pp. 433 and 493-495, 1994.
Rudinger, "Characteristics of the amino acid as componants of a peptide hormone sequence", in Peptide Hormones, Parsons (ed.), University Park Press: Baltimore, MD, pp. 1-7, Jun. 1976.
Dykhuizen et al., "Recombination in Escherichia coli and the definition of biological species", J. Bacteriol. 173 (22): 7257-7268, Nov. 1991.
GenBank Acc. No. M64325, Dykhuizen et al., "E. coli (strain ECOR16) 6-phosphogluconate dehydrogenase (gnd) gene, complete cds.", US National Library of Medicine, Dec. 1991.

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