Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2007-08-07
2007-08-07
Berch, Mark L. (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S265100, C544S117000, C544S280000
Reexamination Certificate
active
10829804
ABSTRACT:
The invention provides a novel class of compounds and compositions of Formula I:in which R1, R2and R3are defined herein, that are useful in the treatment or prevention of diseases or disorders associated with kinases, particularly GSK-3β, c-Abl, HER-1, HER-2, KDR, Flt-3, c-Raf-1, PDGFR-β, c-Kit, Flt-4, Flt-1, Tek, c-src, CDK1, PDK1, FGFR-1, FGFR-2, Fer, MAP3K13, EPHA7 and c-Met kinases. The invention further relates to the use of the compounds of the invention as potent inducers of neurogenesis in embryonic stem cells.
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Ding, Sheng; Wu, Tom Y. H.; Brinker, Achim; Peters, Eric C.; Hur, Wooyoung; Gray, Nathanael S.; Schulà, Peter G., Proceedings of the National Academy of Sciences of the United States of America, 100413), 7632-7637 (English) 2003.
Ding Sheng
Gray Nathanael S.
Schultz Peter
Wu Tom
Berch Mark L.
IRM LLC
Moore Susanna
Phil D.
Reid Scott W.
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