6-phenethylaminoalkyl-furo-(3,4-c)-pyridine derivatives and ther

Details 6-phenethylaminoalkyl-furo-(3,4-c)-pyridine derivatives and ther 6-phenethylaminoalkyl-furo-(3,4-c)-pyridine derivatives and ther

1985-10-21

1987-04-21

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546116, A61K 3144, C07D491048

Patent

active

046597190

ABSTRACT:
This invention relates to new 1,3-dihydro-6-[1-cyano-1-isopropyl-N-phenethyl-N-methyl-.omega.-aminoalkyl ]-7-hydroxy-furo-(3,4-c)-pyridine derivatives of the general formula ##STR1## wherein each of A.sub.1 and A.sub.2 independently represents various substituents and to pharmaceutically acceptable salts of said derivatives, to a process for the preparation of the same, comprising reacting, in stoichiometric proportions, at 15.degree.-65.degree. C., in dimethylsulphoxide, a 6-(1-cyano-2-methyl-propyl)-7-hydroxy-furo-(3,4-c)-pyridine derivative with the appropriate N-methyl-N-phenethyl-.omega.-aminoalkyl choride and, finally, to a therapeutic composition of matter comprising as an essential ingredient therein any of said compounds in an amount effective to act as a calcium antagonist or a serotonin antagonist together with an appropriate diluent or carrier.

REFERENCES:
Bockmuhl et al., Annalen, vol. 561, pp. 52-58 & 69-73, (1949).

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