6-pen-vasopressin compounds

Details 6-pen-vasopressin compounds 6-pen-vasopressin compounds

1985-09-18

1987-12-08

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514807, 530315, A61K 3734, C07K 716

Patent

active

047118776

ABSTRACT:
Vasopressin derivatives having unexpected VSP site binding activity whose structures are characterized by a Mpr unit at position 1 and a Pen unit at position 6 are prepared by standard peptide synthetic methods also using an oxidative cyclization of a linear peptide dimercaptan. A representative species is [1-.beta.-mercaptopropionic acid-2-(O-ethyl)-D-tyrosine-4-valine-6-penicillamine-8-arginine]vasopressi n.

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Chem. Abstr., vol. 88 (1978), 676s.
F. L. Stassen et al., J. Pharmacology and Experimental Therapeutics, 223 53 (1982).

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