6-Oxo-trans-octa- and decahydroquinolines

Details 6-Oxo-trans-octa- and decahydroquinolines 6-Oxo-trans-octa- and decahydroquinolines

1986-06-16

1989-05-02

Gersil, Robert

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546 82, 546 83, 546 84, 546156, 546159, 546162, 546164, 546169, 546170, 546178, 546171, 546 15, 549342, 544250, C07D21520

Patent

active

048269867

ABSTRACT:
7- or 8-Substituted, partially hydrogenated pyrazolo[3,4-g]quinoline, thiazolo[4,5-g]quinoline, oxazolo[4,5-g]quinoline, and pyrrolo[3,4-g]quinoline derivatives, and 8- or 9-substituted, partially hydrogenated pyrido[2,3-g]quinazoline derivatives are D-2 dopamine agonists. 6-Oxo-1-substituted-octahydroquinolines and 6-oxo-1-substituted-decahydroquinolines which are additionally substituted in the 3- or 4-position are intermediates useful in preparation of the dopamine agonists. Acetals of 4,6-dioxo-1-substituted-decahydroquinoline 3-carboxylic acid esters enable synthesis of the foregoing compounds.

REFERENCES:
patent: 4198415 (1980-04-01), Kornfeld et al.
patent: 4230861 (1980-10-01), Kornfeld et al.
patent: 4235909 (1980-11-01), Bach et al.
patent: 4273932 (1981-06-01), Matsubara et al.
patent: 4471121 (1984-09-01), Schaus et al.
patent: 4501890 (1985-02-01), Nichols et al.
patent: 4537893 (1985-08-01), Titus et al.
patent: 4647667 (1987-03-01), Schaus
patent: 4659832 (1987-04-01), Schaus et al.
patent: 4778894 (1988-10-01), Schaus et al.
Bach et al., J. Med. Chem. vol. 23, 1980, pp. 481-491.
Nordmann et al., J. Med. Chem., vol. 28, 1985, pp. 367-375.

Affiliated with

Also associated with

Rating

6-Oxo-trans-octa- and decahydroquinolines does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 6-Oxo-trans-octa- and decahydroquinolines, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 6-Oxo-trans-octa- and decahydroquinolines will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-586137