6-Oxamorphinans

Details 6-Oxamorphinans 6-Oxamorphinans

1977-09-08

1979-05-15

Trousof, Natalie

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

424256, 546 97, 542403, C07D49108

Patent

active

041549325

ABSTRACT:
N-substituted 6-oxamorphinans have been found to possess potent analgetic, narcotic antagonist, antitussive, and ADH inhibitory activity. A particularly preferred compound is (-)-17-cyclopropylmethyl-3-hydroxy-6-oxamorphinan. The compounds are prepared by total synthesis and are not derived from opium alkaloids.

REFERENCES:
patent: 3853889 (1974-12-01), Monkovic et al.
patent: 4016167 (1977-04-01), Montzka et al.

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