Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1976-01-23
1976-11-30
Coughlan, Jr., Paul M.
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
2602471L, 2602472A, 260268BQ, 260286Q, 260288A, 260289K, 424258, C07D21522
Patent
active
039949001
ABSTRACT:
Quinolinones having the formula ##SPC1##
And the acid-addition and quaternary ammonium salts thereof, wherein R.sub.1 is hydrogen, alkyl or arylalkyl; R.sub.2 is hydrogen, halogen, trifluoromethyl, alkyl, alkoxy or nitro; Y is O, S, SO or SO.sub.2 ; Z is alkylamino, dialkylamino, 1-pyrrolidinyl, 1-piperidinyl, 4-morpholinyl, 4-alkyl-1-piperazinyl, 4-arylalkyl-1-piperazinyl or 4-hydroxyalkyl-1-piperazinyl; and n is 2, 3, 4 or 5; have useful antidepressant activity.
REFERENCES:
patent: 3201401 (1965-08-01), Krapcho
patent: 3330823 (1967-07-01), Bernstein et al.
patent: 3493570 (1970-02-01), Plostnieks
patent: 3514459 (1970-05-01), Ritter et al.
patent: 3635985 (1972-01-01), Nishimura et al.
patent: 3910924 (1975-10-01), Tamura et al.
Krapcho John
Schwartz Joseph
Barrack Donald J.
Coughlan, Jr. Paul M.
E. R. Squibb & Sons Inc.
Levinson Lawrence S.
Smith Merle J.
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