6-O-substituted ketolides having antibacterial activity

Details 6-O-substituted ketolides having antibacterial activity 6-O-substituted ketolides having antibacterial activity

1997-07-03

1999-02-02

Knode, Marian C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 72, 536 74, A61K 3170, C07H 1708

Patent

active

058665498

ABSTRACT:
Antimicrobial compounds having the formula ##STR1## as well as pharmaceutically acceptable salts, esters or prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of the compounds.

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patent: 5561118 (1996-10-01), Agouridas et al.
C!Erythromycin to Eschrichia coli Ribosomes," Antimicrobial Agents and Chemotherapy, 6(4), 479-488 (Oct. 1974).
Pestka et al., (II), "Correlation of Effects of Erythromycin Analogues on Ribosomes," Antimicrobial Agents and Chemotherapy, 6(4), 488-491 (Oct. 1974). Escherichia coli Ribosomes by Erythromycin Derivatives," Antimicrobial Agents and Chemotherapy, 6(1), 39-45 (Jul. 1974).
Pestka et al. (IV), "Induction of Erythromycin Resistance in Staphylococcus aureus by Erythromycin Derivatives," Antimicrobial Agents and Chemotherapy, 9(1), 128-130 (Jan. 1976).
LeMahieu et al., "Glycoside Cleavage Reactions on Erythromycin A. Preparation of Enrythronolide A," J. Medicinal Chem., 17(9), 953-956 (Sep. 1974).

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