6-O-substituted erythromycin ketolides having antibacterial acti

Details 6-O-substituted erythromycin ketolides having antibacterial acti 6-O-substituted erythromycin ketolides having antibacterial acti

1998-11-04

2000-11-14

Tsang, Cecilia

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 74, 536124, 514 29, C07H 1708

Patent

active

061471976

ABSTRACT:
Antimicrobial compounds having the formula ##STR1## as well as pharmaceutically acceptable salts, esters or prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of the compounds.

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Pestka et al. (I), "Effect of Erythromycin Analogues on Binding of [.sup.14 C]Erythromycin to Escherichia coli Ribosomes," Antimicrobial Agents and Chemotherapy, 6(4), 479-488 (Oct. 1974).
Pestka et al. (II), "Correlation of Effects of Erythromycin Analogues on Intact Bacteria and on [.sup.14 C]Erythromycin Binding to Escherichia coli Ribosomes," Antimicrobial Agents and Chemotherapy, 6(4), 488-491 (Oct. 1974).
Pestka et al. (III), "Inhibition of [.sup.14 C]Chloramphenicol Binding to Escherichia coli Ribosomes by Erythromycin Derivatives," Antimicrobial Agents and Chemotherapy, 6(1), 39-45 (Jul. 1974).
Pestka et al. (IV), "Induction of Erythromycin Resistance in Staphylococcus aureus by Erythromycin Derivatives," Antimicrobial Agents and Chemotherapy, 9(1), 128-130 (Jan. 1976).
LeMahieu et al., "Glycoside Cleavage Reactions on Erythromycin A. Preparation of Erythronolide A," J. Medicinal Chem., 17(9), 953-956 (Sep. 1974).
Griesgraber et al., "3-Keto-11, 12-carbazate Derivatives of 6-0-Methylerythromycin A Synthesis and In Vitro Activity," J. Antibiotics, 49(5), 465-477 (May, 1996).

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