6-O-substituted erythromycin compounds and method for making sam

Details 6-O-substituted erythromycin compounds and method for making sam 6-O-substituted erythromycin compounds and method for making sam

1997-04-29

2000-06-13

Peselev, Elli

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 72, 536 74, A61K 3170, C07H 1708

Patent

active

060750111

ABSTRACT:
Antimicrobial compounds having the formula ##STR1## as well as the pharmaceutically acceptable salts, esters and prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of the compounds.

REFERENCES:
patent: 5444051 (1995-08-01), Agouridas et al.
Chemical Abstracts, vol. 118, No. 11 (Mar. 1993), p 18, col. 1, S. Omura et al., "Preparation of Erythromycin A Derivatives as Intermediates for 6-O-Alkylerythromycin".
Chemical Abstracts, vol. 113, No. 15 (Oct. 1990), p. 706, col. 1, S. Morimoto, et al "Preparation of Erythromycin A Derivatives as Intermediates for 6-O-Alkylerythromycin".
Journal of Pharmaceutical Sciences, vol. 79, No. 9 (1989), pp. 783-784, T.Suwa et al., "Uptake of O-Alkyl Erythromycin Derivatives in the Lung Tissue and Cells of Rats".
Canadian Journal of Chemistry, vol. 63, No. 10 (1985), pp. 2814-2818, B. Bernet et al., "Formal Total Synthesis of Erythromycin A. Part II. Preparation of a 1,7-Dioxaspiro (5.5)undecane Derivative of Erythromycin A Seco Acid Methyl Ester from Erythromycin A".
Journal of Antibiotics, vol. 37, No. 2 (1984), pp. 187-189, S. Morimoto et al., "Chemical Modification of Erythromycins. I. Synthesis and Antibacterial Activity of 6-O-Methylerythromycins A".
Journal of Antibiotics, vol. 43, No. 3 (1990), pp. 286-294, S. Morimoto et al., "Chemical Modification of Erythromycins. II. Synthesis and Antibacterial Activity of O-Alkyl of Erythromycin A".

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