6-O-substituted antibacterial erythromycin ketolides and methods

Details 6-O-substituted antibacterial erythromycin ketolides and methods 6-O-substituted antibacterial erythromycin ketolides and methods

1998-11-04

2000-06-13

Crane, L. Eric

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 74, 514 29, C07H 1708, A61K 3170

Patent

active

060751339

ABSTRACT:
Antimicrobial compounds having the formula as well as pharmaceutically acceptable sats, esters or prodrugs thereof, pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of the compounds.

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patent: 5631355 (1997-05-01), Asaka et al.
Pestka et al. (I), "Effect of Erythromycin Analogues on Binding of [.sup.14 C]Erythromycin to Escherichia coli Ribosomes," Antimicrobial Agents and Chemotherapy, 6(4), 479-488 (Oct. 1974).
Pestka et al. (II), "Correlation of Effects of Erythromycin Analogues on Intact Bacteria and on [.sup.14 C]Erythromycin Binding to Escherichia coli Ribosomes," Antimicrobial Agents and Chemotherapy, 6(4), 488-491 (Oct. 1974).
Pestka et al. (III), "Inhibition of [.sup.14 C]Chloramphenicol Binding to Escherichia coli Ribosomes by Erythromycin Derivatives," Antimicrobial Agents and Chemotherapy, 6(1), 39-45 (Jul. 1974).
Pestka et al. (IV), "Induction of Erythromycin Resistance in Staphylococcus aureus by Erythromycin Derivatives," Antimicrobial Agents and Chemotherapy, 9(1), 128-130 (Jan. 1976).
LeMahieu et al., "Glycoside Cleavage Reactions on Erythromycin A. Preparation of Erythronolide A," J. Medicinal Chem., 17(9), 953-956 (Sep. 1974).

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