6-nitroprostaglandin derivatives

Details 6-nitroprostaglandin derivatives 6-nitroprostaglandin derivatives

1985-07-19

1987-03-10

Chan, Nicky

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514573, 549214, 549302, 549414, 549415, 549421, 549422, 549473, 549475, 556418, 560 21, 560118, 560121, 562435, 562500, 562503, A61K 31215, A61K 3125, C07C 6974

Patent

active

046491562

ABSTRACT:
The present invention provides a novel 6-nitroprostaglandin derivatives of the formula (I) ##STR1## wherein A, n, R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are as defined in claim 1.
The 6-nitroprostaglandin derivatives is useful as medicines because of its excellent pharmacological activities including platelet aggregation inhibiting activity, blood pressure lowering activity and anti-ulcerous activity, and useful as intermediate for other pharmaceutically active compounds such as 6-oxoprostaglandin derivatives, prostaglandin E.sub.1 derivatives, etc.

REFERENCES:
patent: 3969396 (1976-07-01), Yankee et al.
patent: 4227011 (1980-10-01), Chen et al.
patent: 4269995 (1981-05-01), Sih
Tanaka et al., Tet. Lett., 24 (38), 4103-4 (1983).

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