6'N-Alkyl- and 6',6'-di-N-alkyl derivatives of fortimicins A and

Details 6'N-Alkyl- and 6',6'-di-N-alkyl derivatives of fortimicins A and 6'N-Alkyl- and 6',6'-di-N-alkyl derivatives of fortimicins A and

1977-12-21

1980-05-27

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated via claimed linking group, bond, chelating agent,...

536 17R, 536 4, A61K 3171, C07H 1522

Patent

active

042050707

ABSTRACT:
Novel fortimicin antibiotics represented by the formula ##STR1## wherein R.sub.1 is loweralkyl, R.sub.2 is hydrogen or loweralkyl and R.sub.3 is selected from the group consisting of hydrogen, acyl, hydroxyacyl, aminoacyl, N-monoloweralkylaminoacyl, N,N-diloweralkylaminoacyl, hydroxy-substituted aminoacyl or an aminoacid residue, loweralkyl, hydroxyloweralkyl, aminoloweralkyl, N-monoloweralkylaminoloweralkyl, N,N-diloweralkylaminoloweralkyl or hydroxy-substituted aminoloweralkyl; and the pharmaceutically acceptable salts thereof, intermediates useful in their preparation, compositions employing the compounds and methods of using the compounds.

REFERENCES:
patent: 3929762 (1975-12-01), Umezawa et al.
patent: 3931400 (1976-01-01), Nara et al.
patent: 3976768 (1976-08-01), Nara et al.

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