6-Morpholino-3-substituted phenyl-S-triazolo[4,3-b]pyridazines

Details 6-Morpholino-3-substituted phenyl-S-triazolo[4,3-b]pyridazines 6-Morpholino-3-substituted phenyl-S-triazolo[4,3-b]pyridazines

1976-04-08

1977-04-05

Jiles, Henry R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

4242484, 42424858, C07D48704

Patent

active

040161625

ABSTRACT:
6-Morpholino-3-substituted phenyl triazolopyridazine compounds such as 8-methyl-6-morpholino-3-phenyl-s-triazolo[4,3-b]pyridazine or 8-methyl-6-morpholino-3-(3,4,5-trimethoxyphenyl)-s-triazolo[4,3-b]pyridazi ne are prepared by the reaction of the corresponding substituted benzoyl halide with a 3-hydrazino-6-morpholinopyridazine in the presence of a hydrogen chloride acceptor or by the reaction of a 3-halo-6-morpholinopyridazine with a corresponding substituted benzoyl hydrazide. The compounds have pharmacological activity as bronchodilators.

REFERENCES:
Yurugi et al., "Chem. Abstracts," vol. 80, (1974), No. 37073d.

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