6-monoacetylmorphine derivatives useful in immunoassay

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Metal containing – e.g. – chromoproteins – ferritin,...

Reexamination Certificate

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C530S402000, C530S807000

Reexamination Certificate

active

11303903

ABSTRACT:
Analogs of 6-monoacetyl morphine (6-MAM) are described. These include analogs derivatized at either the C-3 position, the C-6 position, or the nor position of the molecule. These analogs allow for elaboration with linkers terminated by a functional group such as an activated ester, the functional groups being useful for attaching the molecule to other entities such as proteins, polysaccharides, and reporter groups.

REFERENCES:
patent: 5843900 (1998-12-01), Cheronis et al.
patent: 6262265 (2001-07-01), Rouhani et al.
Hutchison, M. et al., “Diacetylmorphine degradation of 6-monoacetylmorphine and morphine in cell culture: implications for new in vitro studies,” European Journal of Pharmacology 453 (2002) 27-32.
O'Neal, C. et al., “Simultaneous determination of Acetylcodeine, Monacetylmorphine and Other Opiates in Urine by GC-MS,” Journal of Analytical Toxicology, vol. 21, Oct. 1997, 427-432.
Staub, C. et al., “Detection of Acetylcodeine in Urine as an Indicator of Illicit Heroin Use: Method Validation and Results of a Pilot Study,” Clinical Chemistry 47:2 (2001) 301-307.

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