6'-Modified fortimicin compounds

Details 6'-Modified fortimicin compounds 6'-Modified fortimicin compounds

1979-09-26

1984-02-14

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

424180, A61K 3171, C07H 1704

Patent

active

044317999

ABSTRACT:
Described is a method for the preparation of 6'-modified fortimicin compounds including 6'-epi fortimicin by converting 1,2-di-N-protected fortimicin B into 4,6'-di-N-substituted alkoxycarbonyl-1,2'-di-N-protected fortimicin B which is further converted to 1,2'-di-substituted fortimicin B-4,5-carbamate, a compound whose substitution pattern is particularly suited to modification at the 6'-amino group and novel compounds thereof.

REFERENCES:
patent: 4091032 (1978-05-01), Tadanier et al.
patent: 4169198 (1979-09-01), Martin et al.

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