6-modified bicyclic nucleic acid analogs

Details 6-modified bicyclic nucleic acid analogs 6-modified bicyclic nucleic acid analogs

2008-07-15

2008-07-15

Lewis, Patrick T. (Department: 1623)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S023100, C514S043000

Reexamination Certificate

active

07399845

ABSTRACT:
The present invention provides 6-modified bicyclic nucleoside analogs and oligomeric compounds comprising these nucleoside analogs. In preferred embodiments the nucleoside analogs have either (R) or (S)-chirality at the 6-position. These bicyclicnucleoside analogs are useful for enhancing properties of oligomeric compounds including nuclease resistance.

REFERENCES:
patent: 3687808 (1972-08-01), Merigan, Jr. et al.
patent: 4415732 (1983-11-01), Caruthers et al.
patent: 4458066 (1984-07-01), Caruthers et al.
patent: 4469863 (1984-09-01), Ts'o et al.
patent: 4476301 (1984-10-01), Imbach et al.
patent: 4500707 (1985-02-01), Caruthers et al.
patent: 4668777 (1987-05-01), Caruthers et al.
patent: 4725677 (1988-02-01), Koster et al.
patent: 4845205 (1989-07-01), Huynh Dinh et al.
patent: 4973679 (1990-11-01), Caruthers et al.
patent: 4981957 (1991-01-01), Lebleu et al.
patent: 5013830 (1991-05-01), Ohtsuka et al.
patent: 5023243 (1991-06-01), Tullis
patent: 5034506 (1991-07-01), Summerton et al.
patent: 5118800 (1992-06-01), Smith et al.
patent: 5130302 (1992-07-01), Spielvogel et al.
patent: 5132418 (1992-07-01), Caruthers et al.
patent: 5134066 (1992-07-01), Rogers et al.
patent: RE34069 (1992-09-01), Koster
patent: 5149797 (1992-09-01), Pederson et al.
patent: 5166315 (1992-11-01), Summerton et al.
patent: 5175273 (1992-12-01), Bischofberger et al.
patent: 5177196 (1993-01-01), Meyer, Jr. et al.
patent: 5177198 (1993-01-01), Spielvogel et al.
patent: 5185444 (1993-02-01), Summerton et al.
patent: 5188897 (1993-02-01), Suhadolnik et al.
patent: 5194599 (1993-03-01), Froehler et al.
patent: 5214134 (1993-05-01), Weis et al.
patent: 5216141 (1993-06-01), Benner
patent: 5220007 (1993-06-01), Pederson et al.
patent: 5223618 (1993-06-01), Cook et al.
patent: 5235033 (1993-08-01), Summerton et al.
patent: 5256775 (1993-10-01), Froehler
patent: 5264423 (1993-11-01), Cohen et al.
patent: 5264562 (1993-11-01), Matteucci
patent: 5264564 (1993-11-01), Matteucci
patent: 5276019 (1994-01-01), Cohen et al.
patent: 5278302 (1994-01-01), Caruthers et al.
patent: 5286717 (1994-02-01), Cohen et al.
patent: 5319080 (1994-06-01), Leumann
patent: 5321131 (1994-06-01), Agrawal et al.
patent: 5359044 (1994-10-01), Cook et al.
patent: 5366878 (1994-11-01), Pederson et al.
patent: 5367066 (1994-11-01), Urdea et al.
patent: 5378825 (1995-01-01), Cook et al.
patent: 5386023 (1995-01-01), Sanghvi et al.
patent: 5393878 (1995-02-01), Leumann
patent: 5399676 (1995-03-01), Froehler
patent: 5403711 (1995-04-01), Walder et al.
patent: 5405938 (1995-04-01), Summerton et al.
patent: 5405939 (1995-04-01), Suhadolnik et al.
patent: 5432272 (1995-07-01), Benner
patent: 5434257 (1995-07-01), Matteucci et al.
patent: 5446137 (1995-08-01), Maag et al.
patent: 5453496 (1995-09-01), Caruthers et al.
patent: 5455233 (1995-10-01), Spielvogel et al.
patent: 5457187 (1995-10-01), Gmeiner et al.
patent: 5459255 (1995-10-01), Cook et al.
patent: 5466677 (1995-11-01), Baxter et al.
patent: 5466786 (1995-11-01), Buhr et al.
patent: 5470967 (1995-11-01), Huie et al.
patent: 5476925 (1995-12-01), Letsinger et al.
patent: 5484908 (1996-01-01), Froehler et al.
patent: 5489677 (1996-02-01), Sanghvi et al.
patent: 5491133 (1996-02-01), Walder et al.
patent: 5502177 (1996-03-01), Matteucci et al.
patent: 5508270 (1996-04-01), Baxter et al.
patent: 5514785 (1996-05-01), Van Ness et al.
patent: 5519126 (1996-05-01), Hecht
patent: 5519134 (1996-05-01), Acevedo et al.
patent: 5525711 (1996-06-01), Hawkins et al.
patent: 5527899 (1996-06-01), Froehler
patent: 5536821 (1996-07-01), Agrawal et al.
patent: 5541306 (1996-07-01), Agrawal et al.
patent: 5541307 (1996-07-01), Cook et al.
patent: 5550111 (1996-08-01), Suhadolnik et al.
patent: 5552540 (1996-09-01), Haralambidis
patent: 5561225 (1996-10-01), Maddry et al.
patent: 5563253 (1996-10-01), Agrawal et al.
patent: 5565350 (1996-10-01), Kmiec
patent: 5565555 (1996-10-01), Froehler et al.
patent: 5567811 (1996-10-01), Misiura et al.
patent: 5571799 (1996-11-01), Tkachuk et al.
patent: 5576427 (1996-11-01), Cook et al.
patent: 5587361 (1996-12-01), Cook et al.
patent: 5587469 (1996-12-01), Cook et al.
patent: 5591722 (1997-01-01), Montgomery et al.
patent: 5594121 (1997-01-01), Froehler et al.
patent: 5596086 (1997-01-01), Matteucci et al.
patent: 5596091 (1997-01-01), Switzer et al.
patent: 5597909 (1997-01-01), Urdea et al.
patent: 5602240 (1997-02-01), De Mesmaeker et al.
patent: 5608046 (1997-03-01), Cook et al.
patent: 5610289 (1997-03-01), Cook et al.
patent: 5610300 (1997-03-01), Altmann et al.
patent: 5614617 (1997-03-01), Cook et al.
patent: 5618704 (1997-04-01), Sanghvi et al.
patent: 5623065 (1997-04-01), Cook et al.
patent: 5623070 (1997-04-01), Cook et al.
patent: 5625050 (1997-04-01), Beaton et al.
patent: 5627053 (1997-05-01), Usman et al.
patent: 5633360 (1997-05-01), Bischofberger et al.
patent: 5639873 (1997-06-01), Barascut et al.
patent: 5645985 (1997-07-01), Froehler et al.
patent: 5646265 (1997-07-01), McGee
patent: 5646269 (1997-07-01), Matteucci et al.
patent: 5652355 (1997-07-01), Metelev et al.
patent: 5652356 (1997-07-01), Agrawal
patent: 5658873 (1997-08-01), Bertsch-Frank et al.
patent: 5663312 (1997-09-01), Chaturvedula
patent: 5670633 (1997-09-01), Cook et al.
patent: 5672697 (1997-09-01), Buhr et al.
patent: 5677437 (1997-10-01), Teng et al.
patent: 5677439 (1997-10-01), Weis et al.
patent: 5681941 (1997-10-01), Cook et al.
patent: 5700920 (1997-12-01), Altmann et al.
patent: 5700922 (1997-12-01), Cook
patent: 5721218 (1998-02-01), Froehler
patent: 5750692 (1998-05-01), Cook et al.
patent: 5763588 (1998-06-01), Matteucci et al.
patent: 5792608 (1998-08-01), Swaminathan et al.
patent: 5792747 (1998-08-01), Schally et al.
patent: 5830653 (1998-11-01), Froehler et al.
patent: 6005096 (1999-12-01), Matteucci et al.
patent: 6268490 (2001-07-01), Imanishi et al.
patent: 6426220 (2002-07-01), Bennett et al.
patent: 6600032 (2003-07-01), Manoharan et al.
patent: 6770748 (2004-08-01), Imanishi et al.
patent: 6794499 (2004-09-01), Wengel et al.
patent: 7053207 (2006-05-01), Wengel
patent: 2003/0082807 (2003-05-01), Wengel
patent: 2003/0207841 (2003-11-01), Kaneko et al.
patent: 2003/0224377 (2003-12-01), Wengel et al.
patent: 2004/0014959 (2004-01-01), Sorensen et al.
patent: 2004/0143114 (2004-07-01), Imanishi et al.
patent: 2004/0192918 (2004-09-01), Imanishi et al.
patent: 2004/0219565 (2004-11-01), Kauppinen et al.
patent: WO 94/02499 (1994-02-01), None
patent: WO 94/17093 (1994-08-01), None
patent: WO 99/14226 (1999-03-01), None
patent: WO 02/36743 (2002-05-01), None
patent: WO 2005/121371 (2005-12-01), None
patent: WO 2005/121372 (2005-12-01), None
Hari et al. Nucleic Acids Research Supplement No. 2 (2002), pp. 147-148.
Agrawal (ed.) Protocols for Oligonucleotides and Analogs (1993) Humana Press.
Altschul, S. F. et al. “Basic Local Alignment Search Tool,”J. Mol. Biol.(1990) 215:403-410.
Barany, G. et al., “A New Amino Protecting Group Removable by Reduction. Chemistry of the Dithiasuccinoyl (Dts) Function,”J. Am. Chem. Soc.(1977) 99(22):7363-7365.
Barany, G. et al., “Kinetics and Mechanisms of the Thiolytic Removal of the Dithiasuccinoyl (Dts) Amino Protecting Group,”J. Am. Chem. Soc.(1980) 102(9):3084-3095.
Bass, B. L., “Double-Stranded RNA as a Template for Gene Silencing,”Cell(2000) 101:235-238.
Beaucage, S. L. et al., “Advances in the Synthesis of Oligonucleotides by the Phosphoramidite Approach,”Tetrahedron(1992) 48(12):2223-2311.
Beaucage, S. L. et al., “The Functionalization of Oligonucleotides Via Phosphoramidite Derivatives,”Tetrahedron(1993) 49(10):1925-1963.
Beaucage S. L. et al., “The Synthesis of Specific Ribonucleotides and Unrelated Phosphorylated Biomolecules by the Phosphoramidite Method,”Tetrahedron(1993) 49(46):10441-10488.
Brazma, A. et al., “Gene expression data analysis,”FEBS Letters(2000) 480:17-24.
Carey, F. A. et al.,Advanced Organic Chemistry, Part B: Reactions and Synthesis4thEd. (2001) Kluwer Academic/Plenum Publishers, New York.

Affiliated with

Also associated with

Rating

6-modified bicyclic nucleic acid analogs does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 6-modified bicyclic nucleic acid analogs, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 6-modified bicyclic nucleic acid analogs will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2789319