6-membered ring fused imidazoles as muscarinic agents

Details 6-membered ring fused imidazoles as muscarinic agents 6-membered ring fused imidazoles as muscarinic agents

1996-10-01

1998-03-03

Berch, Mark L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514266, 544276, 544277, A61K 3152, C07D51900, C07D47300

Patent

active

057234680

ABSTRACT:
The compound of the formula: ##STR1## where R.sub.1 is H, alkyl, perhaloalkyl, arylalkyl, alkenyl or alkynyl; R.sub.2 is H when R.sub.4 is other than H, and, when R.sub.4 is H, R.sub.2 is ##STR2## in which R.sub.5 is hydrogen or alkyl; R.sub.3 is hydrogen or halogen; R.sub.4 is H or ##STR3## X and Y are nitrogen and Z is carbon; n is 1 or 2; n.sub.1 is 0, 1, 2, 3, 4, or 5; or a pharmaceutically acceptable salt thereof are centrally active muscarinic agents.

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M. Williams, Curr. Opin. Invest. Drugs 2(5), 541-544 (May 1993).
R. T. Bartus et al., Science 217, 408-417 (Jul., 1982).
Drugs of the Future 18(5), 433-435 (1992).

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