6-membered lactones useful as intermediates for antilipemic meva

Details 6-membered lactones useful as intermediates for antilipemic meva 6-membered lactones useful as intermediates for antilipemic meva

1989-09-07

1991-01-15

Fan, Jane T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549215, C07D49304

Patent

active

049855719

ABSTRACT:
A compound of the formula: ##STR1## wherein R is an unsubstituted benzyl group, a p-nitrobenzyl group, a benzyl group in which the phenyl group is substituted by one or two substituents selected from the group consisting of C.sub.1 -C.sub.4 alkyl groups and C.sub.1 -C.sub.4 alkoxy groups, a phenyl group which is substituted by a C.sub.1 -C.sub.4 alkylenedioxy group or by one or two substituents selected from the group consisting of C.sub.1 -C.sub.4 alkyl groups and C.sub.1 -C.sub.4 alkoxy groups, a C.sub.1 -C.sub.4 trialkylsilyl group, a mono-substituted C.sub.1 -C.sub.4 alkyldiarylsilyl group, a triarylmethyl group, a C.sub.1 -C.sub.4 acyl group, a substituted or unsubstituted benzoyl group, a C.sub.1 -C.sub.4 alkoxycarbonyl group, a substituted or unsubstituted aryloxycarbonyl group, a tetrahydropyranyl group, a benzyloxymethyl group, or a methoxymethyl group.

REFERENCES:
patent: 4837341 (1989-06-01), Tessier et al.
Tetrahedron Letters, vol. 29, No. 11, pp. 1255-1258, 1988, Bruce D. Roth, et al., "Synthesis of a Chiral Synthon for the Lactone Portion of Compactin and Mevinolin".

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