Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1998-06-18
2000-05-09
Davis, Zinna Northington
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546314, 546315, 564 86, 514354, 514631, A61K 3144, C07D21182
Patent
active
060604913
ABSTRACT:
The present application describes 6-membered aromatics of formula I: ##STR1## or pharmaceutically acceptable salt forms thereof, wherein D may be CH.sub.2 NH.sub.2 or C(.dbd.NH)NH.sub.2, which are useful as inhibitors of factor Xa.
REFERENCES:
Kunitada et al., "Factor Xa Inhibitors", Current Pharmaceutical Design, 1996, vol. 2, pp. 531-542.
Shi-Shan Mao, "Factor Xa Inhibitors", Perspectives in Drug Discovery and Design, vol. 1 (1993), pp. 423-430.
Edmunds et al., "Cardiovascular and Pulmonary Diseases", Annual Reports in Medicinal Chemistry, (1996) vol. 31, pp. 51-60.
Tidwell et al., "Strategies for Anticoagulation with Synthetic Protease Inhibitors. Xa Inhibitors Versus Thrombin Inhibitors", Thrombosis Research, (1980) vol. 19, pp. 339-349.
Sturzebecher et al., "Synthetic Inhibitors of Serine Proteinases XXIII. Inhibition of Factor Xa by Diamidines", Thrombosis Research, (1980) vol. 17, pp. 545-548.
Pinto Donald Joseph Phillip
Pruitt James Russell
Quan Mimi Lifen
Wexler Ruth Richmond
Davis Zinna Northington
Dupont Pharmaceuticals
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