6-membered aromatics as factor Xa inhibitors

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

546314, 546315, 564 86, 514354, 514631, A61K 3144, C07D21182

Patent

active

060604913

ABSTRACT:
The present application describes 6-membered aromatics of formula I: ##STR1## or pharmaceutically acceptable salt forms thereof, wherein D may be CH.sub.2 NH.sub.2 or C(.dbd.NH)NH.sub.2, which are useful as inhibitors of factor Xa.

REFERENCES:
Kunitada et al., "Factor Xa Inhibitors", Current Pharmaceutical Design, 1996, vol. 2, pp. 531-542.
Shi-Shan Mao, "Factor Xa Inhibitors", Perspectives in Drug Discovery and Design, vol. 1 (1993), pp. 423-430.
Edmunds et al., "Cardiovascular and Pulmonary Diseases", Annual Reports in Medicinal Chemistry, (1996) vol. 31, pp. 51-60.
Tidwell et al., "Strategies for Anticoagulation with Synthetic Protease Inhibitors. Xa Inhibitors Versus Thrombin Inhibitors", Thrombosis Research, (1980) vol. 19, pp. 339-349.
Sturzebecher et al., "Synthetic Inhibitors of Serine Proteinases XXIII. Inhibition of Factor Xa by Diamidines", Thrombosis Research, (1980) vol. 17, pp. 545-548.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

6-membered aromatics as factor Xa inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 6-membered aromatics as factor Xa inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 6-membered aromatics as factor Xa inhibitors will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1065491

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.