Organic compounds -- part of the class 532-570 series – Organic compounds – Chalcogen in the nitrogen containing substituent
Patent
1976-03-30
1978-03-14
Daus, Donald G.
Organic compounds -- part of the class 532-570 series
Organic compounds
Chalcogen in the nitrogen containing substituent
544 29, 544 30, 544 53, 260455A, 424246, C07D50134, C07D50130, C07D50118, C07D50108
Patent
active
040791793
ABSTRACT:
Cephalosporin compounds having a loweralkoxy or loweralkylthio substituent in the 6-position are prepared by a multi-step total synthesis route using as starting material a glycine ester, which first is reacted to yield a dihydrothiazine, and subsequently condensed with azidoacetyl chloride to form the cepham nucleus, then dehydrated to yield the desired 3-unsaturation. Subsequent reduction and acylation steps are analogous to known chemistry, and yield the novel 6-loweralkoxy- or loweralkylthio-7-amino intermediates and the antibacterially active 6-loweralkoxy or loweralkylthio-7-acylamido end products.
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Christensen Burton G.
Ratcliffe Ronald W.
Daus Donald G.
Levitt Julian S.
Merck & Co. , Inc.
Pfeiffer Hesna J.
Rivers Diana G.
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