6-(Lower alkoxy)-5-(trifluoromethyl)-1-naphthalenecarboxaldehyde

Details 6-(Lower alkoxy)-5-(trifluoromethyl)-1-naphthalenecarboxaldehyde 6-(Lower alkoxy)-5-(trifluoromethyl)-1-naphthalenecarboxaldehyde

1981-11-13

1983-10-04

Helfin, Bernard

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

568319, 568436, 568445, 568634, 568736, 568815, 570185, 562409, 562427, 564265, 564267, C07C 47115

Patent

active

044080778

ABSTRACT:
A process and intermediates for preparing 6-(lower alkoxy)-5-(trifluoromethyl)-1-naphthalenecarboxylic acid derivatives are disclosed. The derivatives are useful for preparing aldose reductase inhibitors. With reference to the process, 1,1,1-trifluoro-5-(2-methylphenyl)-2,3-pentadione 3-oxime is cyclized to give a key intermediate 3,4-dihydro-1-hydroxy-5-methyl-1-(trifluoromethyl)-2(1H)-naphthalenone oxime; and 3,4-dihydro-1-hydroxy-5-methyl-1-(trifluoromethyl)-2(1H)-naphthalenone is aromatized to 5-methyl-1-(trifluoromethyl)-2-naphthalenol with a dehydrating agent.

REFERENCES:
patent: 3977949 (1976-08-01), Rosenberg

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