6-L-dihydroxyethyl-2,4,7-trioxo-8-D-ribityl pteridine and proces

Details 6-L-dihydroxyethyl-2,4,7-trioxo-8-D-ribityl pteridine and proces 6-L-dihydroxyethyl-2,4,7-trioxo-8-D-ribityl pteridine and proces

1973-09-13

1976-03-23

Rush, Raymond V.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2602564C, 424251, C07D47502

Patent

active

039460126

ABSTRACT:
Trioxopteridine derivatives of the formula ##SPC1##
, wherein R.sub.1 is a normal alkyl group having 0 to 6 hydroxyl groups and R.sub.2 is hydrogen or a normal lower alkyl group having 0 to 5 hydroxyl groups, are prepared by catalytically hydrogenating a 6-substituted-5-nitro-2,4-dioxopyrimidine to give a 6-substituted-5-amino-2,4-dioxopyrimidine, and then reacting the latter compound with a compound of the formula R.sub.2 --A--COOR.sub.3, wherein R.sub.3 is hydrogen, lower alkyl, an alkali metal or an alkaline earth metal and A is carbonyl or a group of the formula ##EQU1## wherein R.sub.4 is lower alkyl. The resulting trioxopteridine derivatives have analgesic and antiphlogistic properties and are therefore useful as pharmaceutical medicaments.

REFERENCES:
rowan et al. -J. Chem. Soc. (c), 1968 (4), 452-458.
Pfleiderer -C.A. 52, 18458fg (1958).
McNutt -C.A. 54, 8836d (1960).
Pfleiderer et al. -C.A. 54, 21113-21114 (1960).
Nuebel et al. -C.A. 57, 8569-8571 (1962).
Mitsuda et al. -C.A. 59, 5501e (1963).
Lohrmann et al. -C.A. 60, 9343d (1964).
Kishi et al. -C.A. 69, 59203w (1968).
Suzuki et al. -C.A. 75, 95610j (1971).
Matsuura et al. -C.A. 79, 5523p (1973).

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