6-Keto prostaglandin derivatives

Details 6-Keto prostaglandin derivatives 6-Keto prostaglandin derivatives

1978-11-09

1980-04-08

Waltz, Thomas A.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260559R, 260559B, 260563R, 2605705CA, 260586R, 548253, 424269, 424299, 424320, 424324, 424325, 424330, 424331, 424324, 560121, 562503, A61K 3116, C07C10319, C07C103737

Patent

active

041972570

ABSTRACT:
Prostaglandin (PG.sub.1) derivatives having (1) a 6-keto feature, for example ##STR1## and amides thereof or (2) a 9-deoxy-6,9-epoxy feature together with a 5-halo or 6-hydroxy feature, for example ##STR2## said derivatives having pharmacological activity. Processes for preparing them and the appropriate intermediates are disclosed.

REFERENCES:
patent: 3927197 (1975-12-01), Monkhouse
Pace-Asciak, JACS, 98, 2348 (1976).

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