6-Keto-morphinan analgesics

Details 6-Keto-morphinan analgesics 6-Keto-morphinan analgesics

1981-07-16

1983-06-14

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

424260, 546 45, C07D22128, A61K 31485

Patent

active

043884636

ABSTRACT:
This patent application describes the preparation and properties of novel and highly potent morphinan analgesics. The compounds include narcotic agnoists as well as narcotic antagonists and are represented by the following formula: ##STR1## R.sub.1 =OCH.sub.3, OCOCH.sub.3, H R.sub.2 =CH.sub.3, CH.sub.2 --CH.dbd.CH.sub.2, ##STR2## CH.sub.2 CH.sub.2 C.sub.6 H.sub.5

REFERENCES:
patent: 3914233 (1975-10-01), Mohacsi et al.
Schmidhammer, et al., Heterocycles, vol. 17, pp. 391-394, (1981).
Jacobson, et al., Problems in Drug Dependence, 1981, National Institute on Drug Abuse Research, Monograph, vol. 41, pp. 86-92, (1982).
Zakkrzewski (I), Farmacja Polska, vol. 27, No. 9, pp. 695-698, (1971).
Brossi, et al., Chemical Abstracts, vol. 95, 187481j, (1981).
Reden et al., J. Med. Chem., vol. 22, No. 3, pp. 256-259, (1979).
Chemical Abstracts, Chemical Subject Index (E-O), vol. 76, Jun. 30, 1972, morphinan, morphin-6-one.
Hsu et al., Heterocycles, 1979, 13 (Spec. Issue), 259-61.
Hsu et al., Helv. Chim. Acta 1980, 63(7), 2042-5.
Rozwadowska et al., Can. J. Chem. 1980, 58(17), 1855-9.
Zakrzewski, Chemical Abstracts, vol. 76, 50006w (1972).

Affiliated with

Also associated with

Rating

6-Keto-morphinan analgesics does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 6-Keto-morphinan analgesics, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 6-Keto-morphinan analgesics will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-164710