6-(hydroxymethyl-ethyl)pyridines

Details 6-(hydroxymethyl-ethyl)pyridines 6-(hydroxymethyl-ethyl)pyridines

1997-06-27

1998-12-15

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546 14, 546250, 546339, 546342, A61K 3144, C07F 702, C07D21330, C07D21355

Patent

active

058497498

ABSTRACT:
The 6-(hydroxymethyl-ethyl)pyridines are prepared by a process in which the 3-hydroxymethylpyridines which are hydroxyl-protected in the 6-position are oxidized to the 3-aldehyde, this is then converted into the corresponding oxoheptenoic acid derivative using a Wittig-Homer reaction, after this the oxo group is reduced to the hydroxyl group and then the isomers are separated by chromatography. The 6-(hydroxymethyl-ethyl)pyridines are suitable as active compounds in medicaments, in particular in medicaments having antiarteriosclerotic activity.

REFERENCES:
patent: 4231938 (1980-11-01), Monaghan et al.
patent: 4319039 (1982-03-01), Albers-Schonberg
patent: 4925852 (1990-05-01), Kessler et al.
patent: 4997837 (1991-03-01), Chucholowski et al.
patent: 5006530 (1991-04-01), Angerbauer et al.
patent: 5169857 (1992-12-01), Angerbauer et al.
patent: 5177080 (1993-01-01), Angerbauer et al.
patent: 5401746 (1995-03-01), Angerbauer et al.
patent: 5409910 (1995-04-01), Angerbauer et al.
patent: 5418243 (1995-05-01), Angerbauer et al.
Journal of Chromatography, 162 (1979), pp. 281-292.

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