Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1985-04-04
1990-12-04
Robinson, Douglas W.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514913, 548166, A61K 31425, C07D27762, C07D27768, C07D27776
Patent
active
049754475
ABSTRACT:
A topical composition for eye treatment of glaucoma, comprising a small but pharmaceutically effective amount of an analog of benzothiazole-2-sulfonamide. The most preferred compound is 6-hydroxyethoxy-2-benzothiazolesulfonamide. The invention also relates to a method of topically treating glaucoma with eye drops to reduce intraocular pressure. Finally, disclosed is a method of synthesis of the preferred and highly effective benzothiazole-2-sulfonamide analogs, particularly the 6-hydroxyethoxy-2-benzothiazolesulfonamide compound.
REFERENCES:
patent: 4505923 (1985-03-01), Hoffman, Jr. et al.
Chem. Abst. 102:137644(g) (1985)-Lewis et al.
Chem. Abst. 102:197524(c) (1985)-Eller et al.
Barfknecht Charles F.
Schoenwald Ronald D.
Robinson Douglas W.
University of Iowa Research Foundation
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