6-hydroxyethoxy-2-benzothiazolesulfonamide and topical treatment

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514913, 548166, A61K 31425, C07D27762, C07D27768, C07D27776

Patent

active

049754475

ABSTRACT:
A topical composition for eye treatment of glaucoma, comprising a small but pharmaceutically effective amount of an analog of benzothiazole-2-sulfonamide. The most preferred compound is 6-hydroxyethoxy-2-benzothiazolesulfonamide. The invention also relates to a method of topically treating glaucoma with eye drops to reduce intraocular pressure. Finally, disclosed is a method of synthesis of the preferred and highly effective benzothiazole-2-sulfonamide analogs, particularly the 6-hydroxyethoxy-2-benzothiazolesulfonamide compound.

REFERENCES:
patent: 4505923 (1985-03-01), Hoffman, Jr. et al.
Chem. Abst. 102:137644(g) (1985)-Lewis et al.
Chem. Abst. 102:197524(c) (1985)-Eller et al.

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