6-Hydroxy and 6-oxo-androstane derivatives active on the cardiov

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Cyclopentanohydrophenanthrene ring system doai

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514177, 514182, 514255, 514315, 514396, 544224, 544388, 546195, 5483355, 548336, 548529, 552641, 552622, 552633, A61K 3156, C07J 100

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active

059143240

ABSTRACT:
6-hydroxy and 6-oxo-androstane derivatives of formula (I), active on the cardiovascular system. ##STR1## wherein: the symbol A represents CH--OR, C.dbd.N--OR, CH--CH.dbd.N--OR and C.dbd.CH--N--OR; and R.sup.1, R.sup.2 and R.sup.3 are as defined herein.

REFERENCES:
patent: 2863885 (1958-12-01), Babcock
patent: 3646064 (1972-02-01), Anner et al.
patent: 5444055 (1995-08-01), Cerri et al.
patent: 5583127 (1996-12-01), Cerri et al.
Sergio Bova, et al., Hypertension, vol. 17, No. 6, pp. 944-950, "Effects of an Endogenous Quabainlike Compound on Heart and Aorta", Jun. 1991.
Fabio Celotti, et al., J. Steroid Biochem., vol. 18, No. 4, pp. 397-401, "Effects of 6- and 7-Hydroxy Metabolites of 3.beta., 17.beta.-Dihydroxy-5.alpha.-Androstane on Gonadotrophin and Prolactin Secretion and on Sex Accessories Weight of Male Rats", 1983.
H. J. G. M. Derks, et al., Steroids, vol. 31, No. 2, pp. 289-290 and 302-304, "The Indentification and Quanitification of Three New 6.alpha.-Hydroxylated Corticosteroids in Human Neonatal Urine", Feb. 1978.
Peter H. Jellinck, et al., J. Steroid Biochem. Molec. Biol., vol. 39 , No. 6, pp. 947-951, "Suppression of 5.alpha.-Androstane-3.beta., 17.beta.-Diol Hydroxylase Activity in Rat Pituitary by Cobalt Protoporhyrin: Implications for Testosterone Homeostasis", 1991.
Susumu Miyabo, et al., Folia Endocrinol. Jap., vol. 52, pp. 630-636, "Cortisol Metabolites in Human and Dog Plasma a Comparative Study", 1976, (with partial English translation).
John Orlowski, et al., Endocrinology, vol. 128, No. 2, pp. 872-884, "Epithelial-Stromal Interactions in The Regulation of Rat Ventral Prostate Function: Indentification and Characterization of Pathways for Androgen Metabolism in Isolated Cell Types", 1991.
Kenneth D. R. Setchell, FEBS Letters, vol. 70 , No. 1, pp. 197-200, "6-Hydroxylation, an Important Route in the Metabolism of Corticosteroids by the Baboon: The Fate of Administered Tetrahydrocortisol", Nov. 1976.
John. F. Templeton, et al., J. Chem. Soc. Perkin Trans., vol. 1, pp. 1361-1368, "Synthesis of Ring-A and -B Substituted 17.alpha.-Acetoxypregnan-20-One Derivatives with Potential Activity on the Digital Receptor in Cardiac Muscle", 1987.
John. F. Templeton, et al., Steroids, vol. 49, pp. 383-396, "Structure-Activity Relationships of Progesterone Derivatives that bind to the Digitals Receptor: Modifications in A and B Rings", Apr.-May 1987.
Chemical Abstracts, vol. 114, p. 89, AN-136215d, 1991.
Chemical Abstracts, vol. 109, p. 68, AN-17146u, 1988.
Chemical Abstracts, vol. 119, p. 1037, AN-271486m, 1993.
Chemical Abstracts, vol. 116, p. 87, AN-99567p, 1992.

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