Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1991-03-28
1993-09-14
Springer, David B.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546272, 546269, 548439, C07D40102, A61K 3140
Patent
active
052449114
ABSTRACT:
6-Heterocyclic-4-amino-1,2,2a,3,4,5-hexahydrobenz[cd]indoles are provided which are useful in modifying the function of serotonin in mammals.
REFERENCES:
patent: 2809974 (1957-10-01), Kornfeld et al.
patent: 3336307 (1967-08-01), Shen
patent: 3671541 (1972-06-01), Bormann et al.
patent: 3674801 (1972-07-01), Bormann et al.
patent: 4057560 (1977-11-01), Bormann et al.
patent: 4110339 (1978-08-01), Bach et al.
patent: 4576959 (1986-03-01), Flaugh
patent: 4745126 (1988-05-01), Leander
patent: 4983622 (1991-06-01), Flaugh
patent: 5096908 (1992-03-01), Gidda et al.
Dreteler et al., J. Card. Pharm., 14, 770 (1989).
Dreteler et al., J. Card. Pharm., 17, 488 (1991).
Shepheard et al., Eur. J. Pharm., 186, 267 (1990).
Lucot et al., Pharm. Biochem. & Beh., 33, 627 (1989).
Othmer et al., J. Clin. Psych., 48(5), 201 (1987).
Bowen et al., Ann. Neurol., 32, 112 (1992).
Bowen et al., The Lancet, 339, 132 (1992).
Bowen et al., Trends in Neurosciences, 15, 84 (1992).
Prehn et al., Eur. J. Pharm., 203, 213 (1991).
Dourish et al., Psychopharmacology, 86, 197 (1985).
Hutson et al., Eur. J. Pharm., 129, 347 (1986).
Dourish et al., Psychopharmacology, 94, 58 (1988).
Dourish et al., Brain 5-HT.sub.1A Receptors: Behavioral and Neurochemical Pharmacology, Chapter 18, Ellis Harwood, publisher.
Dourish et al., Brain Res. Bull., 15, 377 (1985).
Montgomery et al., Psychopharmacology, 94, 110 (1988).
Hutson et al., Eur. J. Pharm., 150, 361 (1988).
Dourish et al., Appetite, 7, Suppl., 127 (1986).
Gilbert et al., Psychopharmacology, 93, 349 (1987).
Dourish et al., Psychopharmacology, 95, 185 (1988).
Neill et al., Eur. J. Pharm., 151, 329 (1988).
Dourish et al., Brain 5-HT.sub.1A Receptors: Behavioral and Neurochemical Pharmacology, Chapter 20, Ellis Harwood publisher.
Hilleman et al., Arch. Intern. Med., 152, 350 (1992).
McBride et al., Pharm. Bio. and Beh., 34, 381 (1989).
Flaugh et al., in J. Med. Chem., 1988, 31, 1746-1753.
Kornfeld, et al., J.A.C.S., 78, 3087 (1956).
Kruse, et al., J. Org. Chem., 49, 4761-4768 (1984).
Bach, et al., J. Med. Chem., 1980, 23, 481-491.
Glennon, J. Med. Chem., 30, 1 (1987).
T. W. Greene, Protective Group in Organic Synthesis, John Wiley and Sons (1981) Chapter 7.
J. W. Barton, Protective Group in Organic Synthesis, McOmie, ed., Plunum Press (1973) Chapter 2.
Schoenberg, et al., J. Org. Chem., 39, p. 3327 (1974).
Schoenberg, et al., J. Org. Chem., 39, p. 3318 (1974).
Tetrahedron Letters, 21, 4061 (1980).
Nichols, et al., Org. Prep. & Proc. Int., 9, 277 (1977).
Leanna, et al., Tet. Lett., 30, 3935 (1989).
O. Mitsunobu, Synthesis, Jan. 1981, p. 1.
J. P. Freemen, et al., Synthesis, Dec. 1974, p. 894.
Sugi, et al., Bull Chem. Soc. Jap., 43, p. 1489 (1970).
Morrison & Boyd, Chapter 22, Organic Chemistry, 3rd Ed. (1973).
Wong, et al., J. Neural Transm., 71, 207-218 (1988).
Wong, et al., J. Neural Transm., 64, 251-269 (1985).
Booher Richard N.
Lawhorn David E.
Martinelli Michael J.
Paget, Jr. Charles J.
Schaus John M.
Boone David E.
Eli Lilly and Company
Springer David B.
Taylor Douglas J.
Whitaker Leroy
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