6-Fluoro-5-nitroquinaldine

Details 6-Fluoro-5-nitroquinaldine 6-Fluoro-5-nitroquinaldine

1984-11-15

1985-12-03

Hollrah, Glennon H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546 94, 546165, 546166, 546171, C07D21518

Patent

active

045567131

ABSTRACT:
The compounds 8-bromo-6,7-dihydro-9-fluoro-5-methyl-1-oxo-1H,5H-benzo[ij]quiniolizine-2- carboxylic acid and 8-chloro-6,7-dihydro-9-fluoro-5-methyl-1-oxo-1H,5H,-benzo[ij]quinolizine-2 -carboxylic acid are disclosed as potent antimicrobials. Pharmaceutically-acceptable carboxylate salts, acyl chlorides, esters and alkylaminoalkyl ester salts of the acids are also disclosed.

REFERENCES:
Sveinbjornsson et al., J. Org. Chem., 16, (1951) pp. 1450-1452; C.A. 46: 5588d (1952).
Japan Kokai, 80-118416 9/11/80, C.A. 94: 71503t (1981).
March Adv. Org. Chem., McGraw Hill, NY, N.Y. 1968 pp. 313 and 554.
J. Mirek Chem. Abst., 62, 5252 (1965).
Jones (ed) "Heterocyclic Compounds" Quinolines, vol. 32, Wiley Inters. NY, N.Y. (1979) pp. 596-603.

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