6-fluoro-3,5-dihydroxy carboxylic acids and derivatives thereof

Details 6-fluoro-3,5-dihydroxy carboxylic acids and derivatives thereof 6-fluoro-3,5-dihydroxy carboxylic acids and derivatives thereof

1989-08-04

1993-04-20

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544333, 544335, A61K 31495, C07D23926, C07D40306

Patent

active

052043517

ABSTRACT:
6-Fluoro-3,5-dihydroxy carboxylic acid derivatives of the formula I and the corresponding lactones of the formula II ##STR1## in which R.sup.1 and R.sup.2 have the specified meanings, a process for the preparation of these compounds, the use thereof as medicinal agents and pharmaceutical products are described. In addition, new intermediates for the preparation of the compounds of the formula I or formula II are described.

REFERENCES:
patent: 4681893 (1987-07-01), Roth
patent: 4868185 (1989-09-01), Chucholowski et al.
patent: 4925852 (1990-05-01), Kesseler et al.
M. R. Boots et al., Pharm. Sci. vol. 69 (1980) pp. 506-509.
F. M. Singer et al., Proc. Soc. Exper. Biol. Med., vol. 102 (1959), pp. 370-373.
H. Ferres et al., Tetrahedron Letters vol. 24, (1983), pp. 3769-3772.
G. E. Stokker et al., J. Med. Chem., vol. 29, pp. 170-181 (1986).

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