6-fluoro-1,4-dihydroquinol-4-one-3-carboxylic acid derivatives a

Details 6-fluoro-1,4-dihydroquinol-4-one-3-carboxylic acid derivatives a 6-fluoro-1,4-dihydroquinol-4-one-3-carboxylic acid derivatives a

1991-05-29

1992-04-07

Gray, Bruce

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

C07C22900

Patent

active

051030403

ABSTRACT:
This invention relates to novel 1,7-disubstituted-6-fluoro-1,4-dihydroquinol-4-one-3-carboxylic acid derivatives and certain esters and cation salts thereof. This invention further relates to preparation of the compounds, antibacterial compositions containing the compounds and methods of using the compounds.
This invention also relates to a novel process for preparing novel N-cyclopropyl intermediates useful for preparing certain of the 1,7-disubstituted-6-fluoro-1,4-dihydroquinol-4-one-3-carboxylic acid derivatives of this invention which contain a cyclopropyl substituent at the 1 position as well as other 1,4-dihydroquinol-4-one-3-carboxylic acid derivatives so substituted with cyclopropyl.

REFERENCES:
patent: 2504875 (1950-04-01), Price et al.
patent: 2614121 (1952-10-01), Price et al.
patent: 2638480 (1953-05-01), Glickman
patent: 3449403 (1969-06-01), Patchett et al.
patent: 3472859 (1969-10-01), Lesher
patent: 3485845 (1969-12-01), Davis et al.
patent: 3515745 (1970-06-01), Tull et al.
patent: 3753993 (1973-08-01), Lesher et al.
patent: 3907808 (1975-09-01), Lesher et al.
patent: 3960868 (1976-06-01), Ferrini et al.
patent: 4146625 (1979-03-01), Lee
patent: 4327101 (1982-04-01), Mushika et al.
patent: 4556658 (1985-12-01), Grohe et al.
patent: 4578473 (1986-03-01), Domagala et al.
patent: 4623650 (1986-11-01), Gilligan et al.
patent: 4636506 (1987-01-01), Gilligan et al.
patent: 4665079 (1987-05-01), Culbertson et al.
patent: 4670444 (1987-06-01), Grohe et al.
patent: 4727080 (1988-02-01), Soler
patent: 4762844 (1988-08-01), Grohe et al.
patent: 4880814 (1989-11-01), Chu et al.
patent: 4929613 (1990-05-01), Culbertson et al.
patent: 4945160 (1990-07-01), Kiely et al.
patent: 4956465 (1990-09-01), Schriewer et al.
Kang, J. et al., N--Cyclopropylation of Aromatic Amines, J. Chem. Soc., Chem. Commun, 1987, pp. 897-898.
Yamamoto, H. et al., Novel N--Alkylation of Amines with Organocopper Reagents, J. Org. Chem., 45: 2739-2740 (1980).
Iwao, M. et al., Directed Metalation of Tertiary Benzamides, Ortho N--Aryl Amination and Synthesis of Acridones, J. Am. Chem. Soc. 104: 5531-5533 (1982).
Abstract for JP 143339 (7/1/86).
Abstract for JP 143364 (7/1/86).

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