(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl-alkyl-(2, 9-disub

Details (6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl-alkyl-(2, 9-disub (6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl-alkyl-(2, 9-disub

1991-03-28

1996-01-09

Venkat, Jyothsna

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544282, A61K 31505, C07D47104

Patent

active

054829437

ABSTRACT:
Novel 2,9-disubstituted-4H-pyrido[1,2-a]pyrimidin-4-ones having the formula ##STR1## the pharmaceutically acceptable acid addition salts thereof, and the stereochemically isomeric forms thereof, wherein
Alk represents C.sub.1-4 alkanediyl,
D is a bicyclic heterocycle of formula ##STR2## wherein R.sup.1 represents C.sub.1-4 alkyl, hydroxyC.sub.1-4 alkyl, carboxaldehyde, carboxyl, C.sub.1-10 alkylcarbonyloxyC.sub.1-4 alkyl; each R.sup.2 represents hydrogen or C.sub.1-4 alkyl; R.sup.3 represents C.sub.1-4 alkyl, hydroxyC.sub.1-4 alkyl or methyl substituted with phenyl, 5-methyl-2-furanyl or 3-pyridinyl; and R.sup.4 represents C.sub.1-3 alkyl, phenyl, 5-methyl-2-furanyl or 3-pyridinyl.

REFERENCES:
patent: 4485107 (1984-11-01), Kennis et al.
patent: 4804663 (1989-02-01), Kennis et al.
P. A. J. Janssen et al., "Pharmacology of Risperidone . . . ", CA 108: 179958s (1988).
A. A. H. P. Megens et al., "Differential effects of the new anitpsychotic risperidone on large . . . a comparison with haloperidol", CA 109: 122371m (1988).

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