6-epifumagillols and the pharmaceutical use thereof

Details 6-epifumagillols and the pharmaceutical use thereof 6-epifumagillols and the pharmaceutical use thereof

1990-03-06

1993-04-20

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514255, 514326, 514343, 514444, 514475, 549 60, 549332, 548517, 546226, 546282, 544147, 544374, A61K 31535, A61K 31335, C07D41314, C07D30302

Patent

active

052043452

ABSTRACT:
The present invention relates to a compound of the formula: ##STR1## wherein R.sup.1 is 2-methyl-1-propenyl group or isobutyl group; R.sup.2 is hydrogen atom, an optionally substituted aliphatic hydrocarbon residue or an optionally substituted acyl group, or a salt thereof.
The compound (I) of the invention has, among others, angiogenesis inhibiting activity, cell-proliferation inhibiting activity and immune reaction inhibiting activity, thus being useful as medicines, etc.

REFERENCES:
Corey et al. "Total Synthesis of (.+-.) Fumagillin" CA 76 153444s (1972).
Tarbell et al. II "The Chemistry of Fumagillin" CA 56 2401f (1962).
Belgian Patents Repnt. No. 42/69 col. 1 formula No. II-IV and #731495.
Chemical Patent Index, Basic Abstracts Journal Section B, Week 8706, Abstract No. 87-040948/06, Abstract of JP-A-476/1987.
J. A. DiPaolo, et al., Antibiotics Annual 1958-1959, pp. 541-546.
Journal of American Chem. Society, vol. 83, pp. 3096-3113 (1961).
The Journal of Antibiotics, vol. 41, pp. 999-1008 (1988).

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