Organic compounds -- part of the class 532-570 series – Organic compounds – Unsubstituted hydrocarbyl chain between the ring and the -c-...
Patent
1988-09-19
1991-02-26
Berch, Mark L.
Organic compounds -- part of the class 532-570 series
Organic compounds
Unsubstituted hydrocarbyl chain between the ring and the -c-...
C07D205085, C07D40304, C07D48704
Patent
active
049963147
ABSTRACT:
A compound represented by the formula ##STR1## wherein R.sub.1 represents a lower alkyl group or a lower haloalkyl group; R.sub.2 represents a lower alkyl group, a lower haloalkyl group, an aralkyl group, or a group of the formula --COOR.sub.4 or --SO.sub.2 R.sub.5 in which R.sub.4 represents an aralkyl group or a substituted or unsubstituted alkyl group and R.sub.5 represents an alkyl group or a substituted or unsubstituted aryl group; and R.sub.3 represents a hydrogen atom or a carboxyl protecting group which can be easily split off. This compound is useful in the production of a 6-(disubstituted amino)carbapenem-series antibiotic.
The compounds of the formula ##STR2## wherein R.sub.1 and R.sub.2 are as defined above are important intermediates for the synthesis of the compounds of formula (I) and/or the aforesaid di-(substituted amino) carbapenem-series antibiotics.
REFERENCES:
patent: 4298741 (1981-04-01), Christensen
patent: 4576746 (1986-03-01), Favara et al.
Topics in Antibiotic Chemistry, vol. 3, pp. 123-124.
Kametani et al., Chem. Pharm. Bull., 31(8), pp. 2578-2582.
Herdewijn et al., Nouveau Journal de Chemie, vol. 7, No. 12, pp. 691-695 (1983).
Chida Noritaka
Fukagawa Yasuo
Ishikura Tomoyuki
Watanabe Azuma
Yoshioka Takeo
Berch Mark L.
Sanraku Incorporated
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