Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1990-03-28
1991-08-06
Ivy, C. Warren
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
552201, C07H 1524
Patent
active
050379704
ABSTRACT:
A compound of the formula ##STR1## wherein R.sub.1 represents a hydrogen atom or a hydroxy group, one of R.sub.2 and R.sub.3 represents a hydrogen atom, the other of R.sub.2 and R.sub.3 represents a hydrogen atom or a hydroxy group and X is a hydrogen atom or a trifluoro acetyl group. The N-trifluoroacetyl 7S:9S and 7R:9R derivatives of the .alpha.-glycosides of formula XV can be separated by chromatography on silica gel to obtain, after mild alkaline hydrolysis the wanted 7S:9S .alpha.-glycosides (R.sub.1 =H) as free bases and can eventually be transformed into their corresponding doxorubicin derivatives (R.sub.1 =OH) by known procedures.
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Angelucci Francesco
Arcamone Federico
Penco Sergio
Vanotti Ermes
Covington Raymond
Farmitalia Carlo Erba S.p.A.
Ivy C. Warren
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