6-deoxyanthracyclines

Details 6-deoxyanthracyclines 6-deoxyanthracyclines

1990-03-28

1992-08-11

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C07H 1524

Patent

active

051380420

ABSTRACT:
Anthracycline glycosides useful as antitumor agents of formula XV: ##STR1## wherein R.sub.1 represents a hydrogen atom or a hydroxy group, one of R.sub.2 and R.sub.3 represents a hydrogen atom, the other of R.sub.2 and R.sub.3 represents a hydrogen atom or a hydroxy group and X is a hydrogen atom or a trifluoro acetyl group.

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patent: 4393052 (1983-07-01), Bargiotti et al.
patent: 4465671 (1984-08-01), Angelucci et al.
The Journal of Organic Chemistry, vol. 48, No. 3, 1983, pp. 405-406, American Chemical Society; S. Penco: "Regiospecific total synthesis of 6-deoxyanthracyclines: 4-demethoxy-6-deoxydaunorubicin".
Tetrahedron, vol. 40, No. 22, 1984, pp. 4677-4683, Pergamon Press Ltd.; S. Penco et al.: "Regiospecific total synthesis of 6-deoxyanthracyclines".
Tetrahedron letters, vol. 22, No. 9, 1981, pp. 811-814, Pergamon Press Ltd., Oxford, GB; Jhillu Yaday et al.: "Regiospecific synthesis of (+)-deoxyanthracyclionones", pp. 811-813.
Chemical Abstracts, vol. 98, No. 7, Feb. 14, 1983, No. 7, Feb. 14, 1983, No. 46929m,; T. McCabe: "Structural studies of biologically interesting natural products".
Journal of the Chemical Society Chemical Communications, No. 8, 1984, pp. 530-531; Francesco Angelucci et al.: "Regiospecific total synthesis of 6-deoxyanthracyclines: 6-Deoxycarminomycin".

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