6-Deoxy-6-azido-14-hydroxy-7,8-dihydroisomorphine or a pharmaceu

Details 6-Deoxy-6-azido-14-hydroxy-7,8-dihydroisomorphine or a pharmaceu 6-Deoxy-6-azido-14-hydroxy-7,8-dihydroisomorphine or a pharmaceu

1977-05-10

1979-03-13

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

424260, C07D48906, A61K 31485

Patent

active

041442369

ABSTRACT:
A process for the preparation of pharmaceutically acceptable 3-protected derivatives of 6-deoxy-6-azido-14-hydroxy-7, 8-dihydroisomorphine, selected from the group which consists of 3-O-acetyl-6-deoxy-6-azido-14-hydroxy-7, 8-dihydroisomorphine, 3-O-tetrahydropyranyl-6-deoxy-6-azido-14-hydroxy-7, 8-dihydroisomorphine and 3-O-methylenemethoxy-6-deoxy-6-azido-14-hydroxy-7, 8-dihydroisomorphine, and the salts of these compounds which comprise the following steps:

REFERENCES:
patent: 3880862 (1975-04-01), Meltzer
patent: 3880863 (1975-04-01), Meltzer
patent: 3882127 (1975-05-01), Meltzer
Knoll et al. (W), Archives Internationales de Pharmacodynamie et de Therapie, vol. 210, No. 2, Aug. 1974, pp. 241-249.
Bognar et al., Acta Chim (Budapest), 58 (2), pp. 203-205 (1968).
Bognar et al., Magy. Kem. Foly., 74 (11), pp. 526-530 (1968).
Knoll et al., Orvostudomany, 22 (3-4), pp. 265-284 (1971).
Bognar et al., Magy. Kem. Foly., 78 (5), pp. 223-228 (1972).
Bognar et al., Acta Chim (Budapest), 74 (1), pp. 99-109 (1972).

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