6' Carbonate esters of zearalanol and its derivatives

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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549270, A61K 31365, C07D31300

Patent

active

047512393

ABSTRACT:
6' carbonate esters of zearalanol and its derivatives are used to promote growth in ruminants. The compounds have the structural formula: ##STR1## wherein R.sub.1 and R.sub.2, which may be the same or different, are H, X, or COX, where X is an alkyl group having from 1-6 carbon atoms; and R is an alkyl group or a Br or Cl substituted alkyl group having from 1-12 carbon atoms.

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Hidy et al., "Zearalenone and Some Derivatives: Production and Biological Activites", Adv. Appl. Microbiol., 22:59-82, (1977).
Shipchandler, "Chemistry of Zearalanone and Some of Its Derivatives", Heterocycles, 3(6):471-520, (1975).
Peters et al., "A Stereoselective Synthetic Route to (R)-Zearalanone", J. Med. Chem., vol. 18, No. 2, 215-217, (1975).

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